Admissions

Dr. Lakshmi Revathi

Our research is focused on elucidating the role of heterotypic cell-cell interactions in both normal physiological processes and disease pathogenesis. We aim to identify and characterize molecular markers associated with disease progression, with the ultimate goal of discovering novel therapeutic targets. To complement our experimental work, we are developing in vitro models of disease progression to validate our findings.
Our current focus is on investigating the involvement of developmental pathway genes in the progression of gastric and breast cancer. Additionally, we are exploring the impact of Wnt pathway modulation in lumbar stenosis. We foster strong collaborations with clinicians and computational biologists to advance our research.

Team

Current members

  1. Ms Amrutha Arjunan: Research Scholar (CSIR-NET); RAS Effector mechanisms in Gastric
    Cancer
  2. Ms. Devi: Research Scholar (NFOBC); Notch in metabolic regulation in Breast cancer
  3. Ms Shirley Niveta : Junior Research Fellow (SERB-CRG); Role of Wnt signalling in
    ligamentum flavum hypertrophy

We are actively seeking highly motivated PhD students and postdoctoral fellows to join our team in developing cutting-edge in vitro models of disease progression.

Projects

Principal Investigator:

  1. “Identification and characterization of a nonenzymatic RAS effector as a potential
    tumor suppressor in gastric cancer” funded by CSIR-ASPIRE, Rs 25 Lakhs
  2. “Investigating the role of DEAD-box helicase, DDX20 in Wnt-driven ROS production
    in triple-negative breast cancer” funded by SERB-POWER, Rs 29.8 Lakhs

Co-Principal Investigator:

  1. “Characterisation of Wnt signaling pathway as a potential therapeutic target for
    Ligamentum flavum hypertrophy in Lumbar canal stenosis” funded by SERB-CRG. Rs
    64.5 Lakhs
  2. “Bio-fabrication of bionic nanofibrous cell sheet and 3D printed scaffold combination
    for superior periosteum and bone remodelling ” funded by SERB-CRG . Rs 37 Lakhs
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