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Dr. KAVITHA R THANGARAJ 

Cancer Biology Laboratory

We focus on understanding the mechanisms of cancer development in the colon. Our research investigates the mechanisms underlying inflammation associated with gasotransmitters.
Altered gasotransmitters are known to impact mitochondrial function, and our primary objective is to conduct a functional study of mitochondria.

We employ a combination of biochemistry, cell and molecular biology, cell culture, and live cell imaging technologies to study mitochondrial function.
In addition, our lab has worked on patient samples from Acute Fatty Liver of Pregnancy, analyzing long-chain fatty acid levels in blood using GC-MS technology.

We have also explored animal models, including an Inflammatory Bowel Disease (IBD) mice model and a Monocrotophos poisoning model in Wistar rats.
We are currently planning to extend our research further using advanced animal models.

Team

Current members

  1. Ms Amrutha Arjunan: Research Scholar (CSIR-NET); RAS Effector mechanisms in Gastric
    Cancer
  2. Ms. Devi: Research Scholar (NFOBC); Notch in metabolic regulation in Breast cancer
  3. Ms Shirley Niveta : Junior Research Fellow (SERB-CRG); Role of Wnt signalling in
    ligamentum flavum hypertrophy

We are actively seeking highly motivated PhD students and postdoctoral fellows to join our team in developing cutting-edge in vitro models of disease progression.

Team

I currently have two Chancellor SRF students working on Neuroblastoma and colon cancer cell lines.

We are actively looking for enthusiastic and dynamic Ph.D. students who are willing to pursue a career in cancer biology.

Projects

Current

  • GATE Project (Internal Institute Funding):
    “Role of Hydrogen Sulphide in the Recovery of Colon Cells from Dextran Sodium Sulphate Induced Inflammation”

Past

  1. DST Women Scientist Scheme A:
    “Identifying Hydrogen Sulphide Role in In Vitro Model of Inflammatory Bowel Disease” – Funded for ₹32 Lakhs.
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