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Dr. K. Kaviarasn

Our research is currently studying the role of retinal pericytes, endothelial cells and other microvascular cells in diabetes complications. Microvascular destabilization and the pericyte loss are the initial events that occur as diabetes progresses. We aim to isolate the cells from healthy individuals and Diabetes to identify the differential regulated proteins, lipid metabolites, neurotrophins and others through proteomics and lipidomic approach. Additionally, we are focused on establishing risk factors related to pro and anti-inflammatory bioactive lipids in correlation with HDL function, inflammatory cytokines, to understand the disease progression from prediabetes to type 2 DM. Our goal is to develop a novel diagnostic marker and therapeutic target/drug for diabetic complications and other non-communicable diseases. We also intend to understand the molecular mechanism underlying the disease to develop new drugs for type 2 diabetes by preclinical, cell line in vitro studies and various bioinformatics tools.

 

Team 

Current members

Ms. Sharmila Rajendran (ICMR-SRF): Research Scholar; Microvascular cells heterogeneity in diabetes and its complications

 

Ms. Sandhya Krishnan (ICMR-JRF): Research Scholar; Imbalance of pro and anti-inflammatory bioactive lipids, reverse cholesterol transport (HDL function) in Pre-diabetes and type 2 diabetes.

Ms. Ranjitha R: Research Scholar: Biomarker discovery for risk screening and detection of childhood anomalies in Pregnant Mother

Past Members

Y M.Mounish, Recipient of Summer research fellowship, SRIHER

Nandhini Prakash, Project Assistant, Novartis funded project

Sherine Joana, Recipient of summer research fellowship, SRIHER

Suvashini, Recipient of summer research fellowship, SRIHER

Sutannu patra, Recipient of student fellowship from TNSCST 

 

We are actively looking for skilled PhD students to join our team on novel biomarker discovery, drug target identification and therapy development.

Ongoing Projects

Current 

  1. Imbalance of pro and anti-inflammatory bioactive lipids, reverse cholesterol transport (HDL function) in the progression of prediabetes to type 2 diabetes mellitus. Funding Agency: ICMR-Adhoc Project. Duration: 2022-2025
  2. Proteomic Studies on Microvascular Cells in Diabetes associated complications: Funding Source: ICMR-SRF fellowship: Duration: 2019-2024

 

 

Completed Projects

  1. Association of α-synuclein in prediabetes and its progression to type 2 diabetes: Funding source: TNSCST grant: Duration: May 2023- December 2023
  2. Isolation and characterization of pericytes from healthy neural human retina: Funding source: GATE project (SRIHER)Duration: 2020-2022
  3. Neurotrophins and inflammatory markers in the progression of pre-diabetes to Type 2 Diabetes Mellitus and Diabetic Retinopathy. Funding Source: Novartis Private Limited. Duration: 2018-2020
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