Faculty Profile

Bio

After completing my PhD in the field of molecular genetics, I have been working for the last 16 years on the genomics of complex disorders. Recently with ICMR TSS fellowship received by my student we have completed a study on the role of BDNF, CREB1 and Serotonin receptor gene polymorphisms in the treatment response to antidepressants in patients with major depressive disorders. With the grant–in-aid received from national funding agencies me and my team are working on the complex disorders like chronic periodontitis, prostate cancer and the genetic factors associated with suicidal behaviour.  In this regard we have reported significant association with few variant genotypes and periodontitis, suicidal behaviour. The variant sequences have also been submitted in GenBank sequences. We have also reported a distinct molecular profile of few miRNA gene polymorphisms and its association with chronic periodontitis. All our research has been published in reputed journals.

My special interest is on the genetic factors associated with chronic periodontitis, with the expertise we have developed in this field, we have been granted a project by Department of Health Research, Government of India under Human Resource development category titled “Workshop on Advanced Molecular Biology techniques in Dental-Genetic Research. This project was aimed at training the dental faculties on the molecular biology techniques; we have successfully completed two batches of training.

Educations

B.Sc Zoology (1998)

M.Sc Biochemistry (2000)

PhD in Biomedical Sciences (Human Genetics) 2008

Research Interest

Projects

Workshop on Advanced Molecular Biology techniques in Dental-Genetic Research (CO-PI)

Human Resource development Project funded by Department of Health Research, Government of India:

Publication: Book Material (National) : 1 Janarthanan S, Manikandan R, Annapoorani A. 2022. Cell and Molecular Biology. Tamil Nadu Open University, Chennai. Book Chapters:  (International) : 3 Annapoorani A, Manikandan R, Ravi AV, Janarthanan, S. 2020. Mechanism of quorum sensing and inhibition of quorum sensing mediated virulence by putative natural compounds against gram- negative bacterial pathogens. [Nova Science Publishers] ISBN 978-1-53618-503-4. 2. Annapoorani A, Veera Ravi A, Janarthanan S and Kathiresan K. Antimicrobials from Mangroves – Recent Advances in the Application of Marine Natural Products as  Antimicrobial Agents. Frontiers in Antimicrobial Agents, 2023, Vol. 2, 148-171. Bentham Book Publisher, Singapore.

Effect of SGLT2 inhibitors on mRNA expression in patients with heart failure with reduced ejection fraction (HFrEF)” (Co-PI)

Project funded by Department of Health Research, Government of India

Completed Projects

• Co- Principal Investigator for the ICMR Funded project on “Influence of Clonal Hematopoiesis of Indeterminate Potential (CHIP) in patients with coronary artery disease”

• Co- Investigator for the ICMR Funded project on “Prenatal Exposure to Air Toxics and Adverse Birth Outcome: An Integrated Rural-Urban Mother-Child Prospective Cohort Study”

• CO-PI/ Mentor for the DBT- BioCARe project on “Urinary microRNAs as Potential Biomarkers for childhood Nephrotic Syndrome”

• Principal Investigator for the DBT funded project on “Study on the role of mir-20, mir-146, mir-196 and mir-499 gene polymorphisms in prostate cancer

• Principal Investigator for the DST funded project on “Study on the role of HLA –C and KIR genes in unexplained recurrent spontaneous abortion”

• Co- Investigator for the ICMR-NIH Funded Collaborative study “Genetics Of Type 2 Diabetes In India: A Multicentric Population Specific Family Genetic Study”

• Co- Principal Investigator in the Centre for Advance Research on Air Pollution an ICMR funded project “ICMR – CAR– “Role of Gene Environment Interactions in Modifying Associations between Exposure to Air pollution and Birth Weight”

• Co- Investigator for the DST funded project on IL 1 gene polymorphism in chronic periodontitis – a causal or casual association

• Co- Investigator for the ICMR funded project on A population Pharmacokinetic & pharmacogenetic study on capox therapy on colorectal cancer patients

 

Awards & Recognitions

News

Membership

Indian Society of Human Genetics

Life member