I am a postgraduate in Pharmacy with Pharmaceutical Biotechnology as specialization. I am registered pharmacist in Tamil Nadu Pharmacy Council. Pursuing Ph.D in the Department of Biotechnology. My teaching experience is about 17 years since 2007 till date. I have been handling classes for UG and PG for subjects like Pharmaceutical Biotechnology, Advanced Cell Biology, and Health Care Biotechnology, Model organisms in Biomedical Research, and Phytomedicine. My research experience include; Bioactivity Screening of herbal extracts using model organisms like zebrafish, brine shrimp etc., and In vitro toxicity studies. I have guided UG and PG projects ≅40 students for the past 17 years . My current research focus is on drug development: In Vitro Drug Screening, Isolation, Characterization of Bioactive compounds and its Bioactivity Screening especially from protein and peptides and identify a novel therapuetic target against cancer and also peptides for antibacterial properties. I have isolated an antimelanogenic and antimelanoma compound from medicinal plant and screened for its activity by inhibiting the rate limiting enzyme for melanogenesis and expression studies for analyzing the apoptotic activity.
| QUALIFICATION | INSTITUITION/UNIVERSITY | YEAR OF COMPLETION |
| PhD | Sri Ramachandra Institute of Higher Education and Research | 2024 |
| M.Pharm (Pharmaceutical Biotechnology) | Vel’s College of Pharmacy/Dr. M.G.R. Medical University | 2007 |
| B.Pharm | K.K.College of Pharmacy/Dr. M.G.R. Medical University | 2002 |
The increasing rise of breast cancer has made the exploration of newer molecules from natural sources which could combat the adverse effects of various chemotherapeutic agents and improvement in patient’s . Natural polyphenols such as genistein, luteolin, quercetin, apigenin, and resveratrol have been studied and have shown apoptosis in various malignant cells (Singh et al., 2017). Moreover, it reduces inflammation. Pumpkin is a very adaptable food that holds the same position among all other vegetables because of its peel, flesh, and seeds, all of which include exceptional phytochemicals that may be used to cure and prevent various medical conditions.
Different phytoconstituents of the Cucurbito and Solanum such as phenolics, flavonoids, and tocopherols, are rich sources of physiologically active chemicals. The work combines phytochemical screening and various cell based assays to examine the anticancer activities of Cucurbita pepo peel and Solanum melongena extract against MCF-7 breast cancer cells. Sequential extraction of the phytochemicals have been done and screened for bioactive substances. This demonstrates that, when compared to standard, the corresponding concentrations of the plant extract had high anticancer activity. The MTT assay was utilized to evaluate the cytotoxic effect, as it gauges cell viability by measuring mitochondrial activity. The MCF-7 cells were aggregated and distorted. The IC50 value of Cucurbita pepo peel and Solanum melongena peel were determined and it was found to be 67.93 µg/ml and 78.69 µg/ml, respectively. The results showed a dose-dependent, substantial reduction in cell viability, suggesting peel extract’s strong anticancer effects. Staining with AO/EtBr was used to see morphological alterations indicative of apoptosis. Furthermore, unique laddering patterns on agarose gel electrophoresis verified the triggering of apoptosis using DNA fragmentation analysis. These results point to the possibility of Cucurbita pepo peel and Solanum melongena extract as a natural medicinal agent for the treatment of breast cancer by indicating that it causes apoptosis in MCF-7 cells.
TamilNadu Pharmacy Council 9262 / A1