Dr. Lakshmi Revathi Perumalsamy brings over 17 years of experience in molecular cell Biology and signal transduction. Her research focuses on uncovering biomarkers and therapeutic targets for non-communicable diseases, like cancer and neurodegeneration. She has published extensively in top journals and actively reviews for scientific publications and funding agencies.
Dr Lakshmi Revathi Perumalsamy, was educated at Birla Institute of Technology and Sciences, Pilani, (BITS Pilani) and National Centre for Biological Sciences- Tata Institute of Fundamental Research, Bangalore (NCBS-TIFR, PhD). After a brief post-doc stint at NCBS-TIFR, she worked in Indian Institute of Technology Madras as Principal Scientist. She was involved in establishing and setting up protocols for the “National Cancer Tissue Biobank” with Dr Mahalingam at IIT Madras. Dr Lakshmi has extensively contributed to the field of Notch Signaling and its role in cell survival. She has established roles for Notch signalling beyond its canonical functions and identified novel interactors for the same. Dr Lakshmi has elucidated the importance of spatiotemporal signaling in regulatory T-cells function. She is a recipient of DBT award for biology, KVPY fellowship, CSIR-NET fellowship. In addition, she has been awarded several prestigious travel award to give oral presentation in international conferences. She is also a recipient of the Welcome trust DBT India Alliance Early Career fellowship to understand the Role of RAS effector in tumor migration and invasion.
Currently, her primary research interest is in deciphering the signaling network key to circumstantial regulation/dysregulation of homeostasis particularly in cancer. The signalling networks integrate together to set up a control system in the body. This control system monitors the development of an organism from a single cell as well as maintenance of homeostasis. A malfunction or evasion of such a systemic control system at any level would result in diseases including Cancer and neural degeneration. Through development and differentiation, cell-cell interaction plays a key role in transmission of information through the multicellular organism. Integrating different approaches ranging from omics, molecular editing and imaging, the goal is in characterizing these interactions that stabilize or destabilize homeostasis.
Teaching Philosophy
Dr. Lakshmi firmly believes in the power of igniting scientific curiosity and fostering critical thinking skills within future generations of scientists. Her teaching philosophy draws inspiration from the profound wisdom of W.B. Yeats, who advocated for ”teaching children how to think, not what to think,” and aligns with J.F. Kennedy’s vision of education as the ”advancement of knowledge and dissemination of truth.” Dr. Lakshmi endeavours to cultivate a ”scientific temper” – a discerning and evidence-based approach to inquiry – and ”lateral thinking” – the ability to approach problems from unconventional angles – within her students. This, coupled with a rigorous foundation in the fundamental tenets of scientific inquiry, empowers them to become proficient researchers.
Dr. Lakshmi is committed to providing her students with world-class training, equipping them with hands-on experience in cutting-edge methodologies. This encompasses everything from foundational biochemical techniques to sophisticated cellular and molecular tools critical for contemporary research endeavors. Through this, she aspires to empower her students to become proficient researchers and contribute to the advancement of scientific knowledge and development of technological breakthroughs.
Integrated M.Sc (Hons) Biological Sciences with B.E (Hons) Computer Science (BITS – Pilani)
PhD in Biology (NCBS-TIFR)
Post Doctoral Fellowship (NCBS-TIFR)
Principal Investigator
Status: Completed
Funding source : Wellcome Trust/DBT India Alliance Early Career Fellowship . Collaborators : Dr Ganesh Venkataraman (Currently in VIT, Vellore), Dr Mahalingam (IITM) and Dr Madhulika Dixit (IITM). Duration : 2018-2022 Amount : Rs 100 Lakhs
Co-Principal Investigatot
Status: completed
Funding Source: AO Spine 2021 Research Start-up Grant. Collaborators: Dr G. Sudhir (Principal investigator), Spine Surgery, SRMC & RI and Dr Arun Dharmarajan. Duration : 2021-2022. Amount : Rs 20 Lakhs
Principal Investigator
Status : Ongoing
Funding Source: SERB-POWER, Govt of India. Collaborators:
Dr Arun Dharmarajan, Dr Natarajan Bhaskaran, Dr Sandhya Sundaram, and Dr Archana – Pathology, SRMC &RI. Duration : Rs 2021-2024. Amount: 29.8 Lakhs
Co-Principal Investigator
Funding Source: SERB-CRG. Collaborators: Dr G. Sudhir , Spine Surgery, SRMC & RI and Dr Sandhya Sundaram , Pathology, SRMC & RI, Duration : 2023-2026 Amount : Rs 62.5 Lakhs
PhD Guide
Scholar : Amrutha Arjunan (from 2021) :
Funding Source: Founder-Chancellor Shri. N.P.V Ramasamy Udayar Research Fellowship. CSIR -UGC JRF 2021, CSIR-UGC SRF 2023
Phd Guide
Scholar : Devi Maigandan (from 2022)
Funding Source: Founder-Chancellor Shri. N.P.V Ramasamy Udayar Research Fellowship, NFOBC JRF 2022
PhD Co-Guide
Dr Sudhir Ganesan (from 2021)
Post Graduate Dissertation guidance
Student : Dharshini M
Year : 2024
Post Graduate Dissertation guidance
Student : Mohammed Faisal
Year: 2023
Post Graduate Dissertation guidance
Student : Rajini Menon
Year: 2022
Post Graduate Dissertation guidance
Student : Karthiga
Year: 2021
Post Graduate Dissertation guidance
Student : V. Shri Sai Priya, Integrated M.Sc Biomedical Sciences from Bharathidasan university
Year :2020
Under Graduate Project Guidance:
Student : Srinidhi S
Year : 2024
Under Graduate Project Guidance:
Student : Ketan S
Year : 2024
Under Graduate Project Guidance:
Student : Koushik Arikera
Year : 2024
Under Graduate Project Guidance:
Student : Aravind R Sitaraman
Year : 2022
Under Graduate Project Guidance:
Student : Ashwin Rajaseker
Year : 2022
Under Graduate Project Guidance:
Student : Santhosh S A
Year : 2022
Under Graduate Project Guidance:
Student : Helen Shweta C
Year : 2021
Under Graduate Project Guidance:
Student : Srinija V
Year : 2021
Under Graduate Project C0-Guidance:
Student : Naveen Kumar P
Year : 2021
Under Graduate Project Guidance:
Student : BaganSrinath J
Year : 2020
Under Graduate Project Guidance:
Student : P ShraddhaShravani
Year : 2020
Under Graduate Project Guidance:
Student : Mohamed Yazeer
Year : 2020
Chancellor Summer Research Fellowship
Student : Srishti Satyanarayanan
Collaborator: Dr Lalitha, BMS
Awarded year : 2023
Chancellor Summer Research Fellowship
Student : Harini Anna
Awarded year : 2023
Chancellor Summer Research Fellowship
Student : Suchita Ganesan
Collaborator : Dr Sudhir Ganesan, Dept. Spine Surgery, SRIHER
Awarded year : 2021
Chancellor Summer Research Fellowship
Student : Harshada S Bharadwaj
Collaborator : Dr Manjula, SMART, SRIHER
Awarded year : 2021
Chancellor Summer Research Fellowship
Student : Thulasi S Rajasekaran
Awarded year : 2021
Chancellor Summer Research Fellowship
Student : Zainab Shabbir Rasheed
Collaborator : Dr Balaji, FCR, SRIHER
Awarded year : 2024
Article titled “Navigating Tumour Microenvironment and Wnt Signalling Crosstalk: Implications for Advanced Cancer Therapeutics” received “Prof. S. P. Thyagarajan Award” for Best Research Publication in Faculty of Biomedical Sciences and Technology published in “Cancers” with Highest Impact Factor of 4.5.
Article titled “Structural–energetic basis for Coupling between Equilibrium Fluctuations and Phosphorylation in a Protein Native Ensemble” selected for the Prof. S. P. Thyagarajan Award for Best Research Publication -2022 in the in Faculty of Biomedical Sciences & Technology published in “ACS Central Science” with Highest Impact Factor in 2022 (18.73).
conducted by Suraasa
conducted by Suraasa
Awarded by Department of Biotechnology, government of India for excellent performance in biology in AISSCE 2001.
AACR ID- 347575