I am an Assistant Professor at the Department of Biomedical Sciences and my research focus is on exploring therapeutic potential of phytochemicals and their drug targets through in silico and in vitro approach. I have worked on in vitro and in vivo models of metabolic diseases such as diabetes and cancer. Drug-induced liver toxicity has been my thrust area and I have worked on rat models for hepatotoxicity exploring the toxicity ameliorating effects of various natural and synthetic antioxidants. My current research interest is to study the significance of genetic variants of critical genes and their role in the disease progression and drug resistance in cancer.
This project is awarded under the GATE (Intramural) scheme of SRIHER and involves in vitro studies to identify the involvement of oxidative stress and/or inflammatory mechanisms in bedaquiline treated HuH7 cell line and an in silico model to identify potential lead compounds which could be further used in experimental methods to test their effectiveness in ameliorating bedaquiline-induced liver injury.
This project is funded through the Chancellor’s Summer Research Fellowship of SRIHER. This study is an effort to explore the efficacy of hormone modulators as efficient pharmacological interventions for Non-Alcoholic Fatty Liver Disease. This would aid in understanding the underlying mechanisms of the aforementioned action of the test compounds.
This project is funded through the Chancellor’s Summer Research Fellowship of SRIHER. This study aimed at providing insights into the extent of use of antibiotics by the poultry farms in Tamil Nadu and might aid analyze the threat to human health through antimicrobial resistance by consumption of poultry products.
HPV-16 and HPV-18 are high-risk HPV strains which utilize the essential roles of the HPV E1 and E2 proteins in immune evasion and replication, are being studied as novel therapeutic targets to develop therapeutic vaccines. Identifying targets for triggering strong immune responses against HPV using computational techniques like peptide design and epitope prediction contribute in developing of vaccines. This will have a promising approach for treating illnesses linked to HPV.
Considering the significant role of the KEAP1-NRF2 pathway in protecting cells from oxidative damage, the ability of phytocompounds to modulate this pathway holds therapeutic promise. The findings of this study would provide a basis for further exploration and development of potential therapeutic agents for oxidative stress and impaired NRF2 activity associated diseases.