Faculty Profile

Bio

• Thrust area of research is on “Pathobiology”.
• Vibrantly working in the field of multi drug resistance and suppression of bacterial quorum sensing mediated virulence gene expression and biofilm formation in multi-drug resistant bacterial pathogens through various genomics and proteomics approach.
• Identification of quorum sensing inhibitory potential of novel/potential phytochemicals from various natural resources.
• Studying on anti-aggregation of amyloid beta peptide and its mediated neurotoxicity in Alzheimer’s studies.
• Future goals: Nanomaterials based targeted drug delivery and immune-modulatory studies in Caenorhabditis elegans animal model system
  

Publication: Book Material (National) : 1

• Janarthanan S, Manikandan R, Annapoorani A. 2022. Cell and Molecular Biology. Tamil Nadu Open University, Chennai.

Book Chapters:  (International) : 3                                                                                    

• Annapoorani A, Manikandan R, Ravi AV, Janarthanan, S. 2020. Mechanism of quorum sensing and inhibition of quorum sensing mediated virulence by putative natural compounds against gram- negative bacterial pathogens. [Nova Science Publishers] ISBN 978-1-53618-503-4.
• Annapoorani A, Veera Ravi A, Janarthanan S and Kathiresan K. Antimicrobials from Mangroves – Recent Advances in the Application of Marine Natural Products as  Antimicrobial Agents. Frontiers in Antimicrobial Agents, 2023, Vol. 2, 148-171. Bentham Book Publisher, Singapore.

PUBLICATIONS: 

1. Parimalanandhini D,  Annapoorani A,  Sangeetha R, Mahalakshmi K, Livya CM,   Janarthanan S, Manikandan R 2024. Phytol from Scoparia dulcis prevents NF-κB           mediated inflammatory responses during macrophage polarization. 3 Biotech 14(3): doi: 10.1007/s13205-024-03924-9 (Impact Factor: 2.653).
2. Annapoorani A, Vigneshkumar B, Balaji A, Kannapan A, Packiavathy IASV,   Sivaranjani M, Balamurugan K, Janarthanan S and Ravi AV. Anti-infective   potential of plant derived quorum sensing inhibitors against multi drug resistant human   and aquatic bacterial pathogens. World Journal of Microbiology and Biotechnology,  :39(6):147. (Impact Factor: 4.253).
3.  Annapoorani A, Koodalingam A, Beulaja M, Saiprasad G, Chitra P, Stephen A, Palanisamy S, Prabhu NM, You SG, Janarthanan S, Manikandan R. 2021. Eco-friendly    synthesis  of  zinc oxide nanoparticles using Rivina humilis leaf extract and their biomedical applications. Process Biochemistry, 112 (6535).                          DOI:10.1016/j.procbio.2021.11.022. (Impact Factor: 3.751).
4. Annapoorani A, Kalpana B, Musthafa KS, Pandian SK and Ravi AV. 2013.    Antipathogenic potential of Rhizophora spp. against the quorum sensing mediated virulence factors production in drug resistant Pseudomonas aeruginosa. Phytomedicine. 20:956-963 (Impact factor: 5.34).
5.  Annapoorani A, Umamageswaran V, Parameswari R, Pandian SK, Ravi AV. 2012.    Computational discovery of putative quorum sensing inhibitors against LasR and RhlR    receptor proteins of Pseudomonas aeruginosa. Journal of Computer – Aided    Molecular Design. 26:1067-1077 (Impact factor: 3.68).
6.  Annapoorani A, Parameswari R, Pandian SK and Ravi AV. 2012. Methods to    determine antipathogenic potential of phenolic and flavonoid compounds against  urinary pathogen  Serratia marcescens. Journal of Microbiological Methods. 91:208-211. (Impact factor: 2.36).
7.  Annapoorani A, Jabbar AKKA, Musthafa SKS, Pandian SK, Ravi AV. 2012. Inhibition of quorum sensing mediated virulence factors production in urinary pathogen                       Serratia marcescens PS1 by marine sponges. Indian Journal of Microbiology 52:160-166. (Impact factor: 2.46).
8.  Musthafa KS, Ravi AV, Annapoorani A, Packiavathy ISV, Pandian SK. 2010.    Evaluation of antiquorum sensing activity of edible plants and fruits through inhibition    of  the N- acyl homoserine lactone system in Chromobacterium  violaceum and    Pseudomonas aeruginosa. Chemotherapy 56: 333-339 (Impact factor: 2.54).
9.  Musthafa KS, Ravi AV, Annapoorani A, Jayakumararaj R, Pandian SK. 2009. Cross    species signal transfer mediated induction of antibiotic production in Actinomycetes         against  Staphylococcus aureus. Journal of Pharmacy Research. 3: 397-400.
10. Kannappan A, Srinivasan R, Nivetha A, Annapoorani A, Pandian SK and Ravi AV. 2019. Anti-virulence potential of 2-Hydroxy-4- methoxybenzaldehyde against Methicillin resistant Staphylococcus aureus and its clinical isolates. Applied Microbiology and Biotechnology, 103: 6747-6758 (Impact factor: 4.81).
11. Packiavathy IASV, Maruthamuthu S, Gnanaselvan G,  Manoharan S, Paul JPJ, Annapoorani A, Kannappan A and Ravi AV. 2019. The control of microbially induced    corrosion by methyl eugenol-a dietary phytochemical with quorum sensing inhibitory potential. Bioelectrochemistry. 128: 186-192. (Impact factor: 5.37).
12. Tamilarasan K, Annapoorni A, Manikandan R, Janarthanan S. 2021. Isolation, characterization of galactose-specific lectin from Odoiporus longicollis and its antibacterial and anticancer activities. International Journal of Biological Macromolecules, 183: 1119-1135. (Impact factor: 8.025).

Google scholar citation	:	582
Cumulative impact factor	:	45.189
H-index	:	9
i10 index	:	9

Genbank sequence submission

             Molecular characterization (16s rRNA gene analysis) was done for six bacterial isolates namely Pseudomonas aeruginosa AS1 , P. aeruginosa AS2, Psychrobacter aquaticus A1 , P. pseudoalcaligenes A2 , Bacillus spp. SS4 , Streptomyces spp. Ac-6, P. aeruginosa (DI-1), B. licheniformis (DI-2), B. megaterium (DI-3), B. subtilis (DI-4), B. licheniformis (DI-5) and B. amyloliquefaciens (DI-6) and their sequences were submitted in the GenBank with the accession number of GU447237, GU447238, GU447235, GU447236, GU471751, FJ662867, KC346264, KC346259, KC346260, KC346261, KC346262 and KC346263, respectively.

Paper/Posters Presented

1. Antipathogenic potential of epicatechin from Rhizophora apiculata against seudomonas aeruginosa. Annapoorani, B. Kalpana, S. Karutha Pandian and Veera Ravi in National Conference on Role of Microbes in Health, Agriculture and Industry organized by Department of Biotechnology, Alagappa University, Karaikudi, March during 26-27, 2012.
2. Interference of quorum sensing mediated virulence factor production in urinary pathogen Serratia marcescens PS1 by marine sponges. Annapoorani, A.K. Kamil Abdul Jabbar, S. Syed Musthafa, S. Karutha Pandian and A. Veera Ravi in International Conference on regulatory network architecture in bacteria Sastra University, Thanjavur during March 9-11, 2012.
3. Anti-infective potential of morin a flavanoid compound of Artocarpus heterophyllus against Vibrio harveyi. Annapoorani, A. Veera Ravi and S. Karutha Pandian in International Conference on Environmental security for Food and Health (ICEGFH-2012) organized by Dr. K. Kathiresan trust and MDT Hindu College and Vivekananda Kendra held at Kanyakumari during February 16-18, 2012.
4. Farnesol-A potential anti-quorum sensing compound to prevent aquatic bacterial diseases. A. Veera Ravi, I. Sybiya Vasantha Packiavathy, K. Syed Musthafa, Annapoorani and S. Karutha Pandian in Eighth Symposium On Diseases In Asian Aquaculture at Mangalore during November 21-25, 2011.
5. Anti-quorum sensing potential of malonic acid in preventing Vibrio harveyi Khadar Syed Musthafa, I. Sybiya Vasantha Packiavathy, A. Annapoorani, S. Karutha Pandian and A. Veera Ravi in Eighth Symposium on Diseases in Asian Aquaculture at Mangalore during November 21-25, 2011.
6. Multiple antagonistic activity of rosmarinic acid against quorum sensing mediated phenotypic expressions in Gram negative bacterial pathogens. A. Annapoorani and Veera Ravi in 52^nd Annual Conference of Association of Microbiologists in India, organized by Panjab University, Chandigarh during November 3-6, 2011.
7. Computational discovery of novel quorum sensing inhibitors against LasR & RhlR receptor proteins of P. aeruginosa. A. Annapoorani, S. Karutha Pandian and A. Veera Ravi in International Conference on aquatic microbiology (Status, Challenges and Oppurtunities (AMSCO-2010) at CAS in marine biology, Annamalai University, Chidambaram during 2-4 September, 2010.
8. Inhibition of Pseudomonas aeruginosa virulence by the potential QSI compound obtained from the leaves of Avicennia officinalis‟. A. Annapoorani, K. Kalpana, K. Syed Musthafa, I. Sybiya Vasantha Packiavathy, S. Karutha Pandian and A.Veera Ravi in International colloquium on emerging biotechnologies in Agriculture, Animal heath and Productivity, held at Alagappa University, Karaikudi, during February, 22-26, 2009.
9. A comparative analysis of quorum sensing inhibitory activity of mangrove leaves against standard laboratory strain P. aeruginosa PAO1 and its clinical isolate. A. Annapoorani, S. Karutha Pandian and A.Veera Ravi in Biotechnology: Fusion of Advanced Research and Teaching‟ organized by School of Biotechnology, Madurai Kamaraj University, Madurai, January 2-4, 2010.
10. Screening of    AHL    antagonist    from    Ocimum    sanctum    (Lamiaceae).   A. Annapoorani, K. Syed Musthafa, I. Sybiya Vasantha Packiavathy, S. Karutha Pandian and A.Veera Ravi in 77^th Annual Meeting of Society of Biological Chemists‟ (INDIA)  “Impact  of  Basic  and  Translational  Research  on  Medicine, Agriculture and Industry” organized by Department of Biotechnology, IITM, Chennai, December 09-12, 2008.
11. HIV Vaccine in sristi 2005, a National level student technical symposium in Biotechnology held at Sathyabama Institute of Science and Technology, Deemed University, Chennai. March 14-15, 2005.
12. Seminars/Symposia/Workshops Attended
13. Participated in “National workshop on microbial diversity: DNA to database” organized by the Bioinormatics Infrastructure Facility, Alagappa University, Karaikudi during 23-25, February,
14. Participated in “National Symposium cum Workshop on Recent Trends in Structural Bioinformatics and Computer Aided Drug Design” (SBCADD-2012) organized by Department of Bioinformatics, Alagappa University, Karaikudi during 20-23, February, 2012.
15. Participated in “National Workshop on Microbial diversity and phylogenetics” organized by Bioinformatics Infrastructure Facility, Alagappa University during 19-21, January, 2011.
16. Participated in “National Workshop on     Bioinformatics‟     organized     by Bioinformatics Infrastructure Facility, Alagappa University during 10 -12, March 2010.
17. Participated in  “International  Conference  on  Climate  Change  and  Bioresource‟ (ICCCB-2010) organized by Department of Biotechnology, Bharathidasan University, Tiruchirappalli 9-12, February,
18. Participated in International Colloquium on “Emerging Biotechnologies in Agriculture, Animal Health and Productivity‟ (ICEB‟09) organized by Alagappa University, Karaikudi, The Queens University of Belfast and Agri-Food and Biosciences Institute, Belfast 22-26, February
19. Participated in a National level seminar on “Marketing aspects of medicinal plants‟ organized by Department of Biotechnology, Srimad Andavan Arts and Science College,Trichy, January 29-30,
20. Participated in Sristi “05, a National level student technical symposium in Biotechnology organized by Sathyabama Institute of Science and Technology, Deemed University, Chennai, March 14-15,
21. Paricipated in the National Level Seminar on “Recent Trends in Biotechnology‟ organized by Department of Biotechnology. Srimad Andavan Arts and Science College, Trichy, September 30- October 1,
22. Participated in “HERBAL FOCUS 2004 ‟National level seminar on Bio Prospecting: Medicinal Plants And Herbal Products‟ organized by Department of Biotechnology, Srimad Andavan Arts & Science College, Trichy, January 10-12, 2004.

 

 

Educations

Srimad Andavan Arts and Science College, Bharathidasan University Trichy.	B.Sc.,	2006	Biotechnology
Alagappa University, Karaikudi.	M.Sc.,	2008	Biotechnology
Alagappa University, Karaikudi.	Ph.D.,	2014	Biotechnology
University of Madras             Chennai	UGC  Post Doctoral Fellow	2019-2022	Neuro biology
University of Madras             Chennai	Scientist D/ Senior Programme Officer	2022-2024	EIACP Scheme     (MoEF& CC, New Delhi)

Research Interest

Projects

Awards & Recognitions

UGC RFSMS Junior Research Fellowship

Awarded UGC RFSMS Junior Research Fellowship during the period of 01.02.2011-31.03.2011.

CSIR Senior Research Fellowship

Awarded Direct CSIR Senior Research Fellowship during the period of 01.04.2011-31.03.2013.

Won Best Paper Presentation Award

Won the best paper presentation award entitled “Computational discovery of novel quorum sensing inhibitors against LasR & RhlR receptor proteins of   Pseudomonas aeruginosa” A. Annapoorani, S. Karutha Pandian and A.Veera Ravi in the International Conference on Aquatic Microbiology (Status, Challenges and Opportunities) held from 2-4 September, 2010 at Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Tamil Nadu, India.

Won Best Poster Award

Won the best poster award for the poster presentation entitled “Anti-quorum sensing potential of malonic acid in preventing Vibrio harveyi infection”. K. Syed Musthafa,  Sybiya Vasantha Packiavathy, A. Annapoorani, S. Karutha Pandian and A.Veera  Ravi in Eighth Symposium on Diseases in Asian Aquaculture at Mangalore during  November 21-25, 2011.

5. Editor in the article: EIACP Newsletter: ISSN-0974-1550

Expert lecture in the “Summer Training Programme in Biology” (STPIB-2023)

Expert lecture in the “Summer Training Programme in Biology” (STPIB-2023) organized by The Academy of Sciences, Chennai from 3^rd June to 17^th June 2023.

Expert lecture in the Summer Training Programme on “Biological Sciences”

Expert lecture in the Summer Training Programme on “Biological Sciences” jointly organized by the Science City, Department of Higher Education, Government of Tamil Nadu & Department of Zoology, University of Madras, Guindy Campus, Chennai – 600 025.

Expert lecture in the “Summer Training Programme in Biology” (STPIB-2022)

Expert lecture in the “Summer Training Programme in Biology” (STPIB-2022) organized by The Academy of Sciences, Chennai from 3^rd June to 17^th June 2022.

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