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Dr. S. Jawahar Babu

Penultimate Treatment Line for Fracture Repair – A Clinical Trial Using Bone Adhesive in Managing Fractured Mandible

Maxillofacial surgeons are exploring the use of biodegradable and biocompatible adhesives for bone fractures, focusing on biocompatibility, degradability, and bond strength.

Bone Adhesive (Tetranite), a novel mineral-organic bone adhesive, reacts in an aqueous medium to form a self-setting material that adheres to bone even in wet conditions.

Preclinical studies have shown that bone adhesive enhances primary human osteoblast cell viability and proliferation at fracture sites.

A prospective, randomized clinical trial aims to assess bone adhesive’s effectiveness in stabilizing mandibular fractures over a period of two years.

This study involves adults with mandibular fracture non-union due to trauma, comparing bone adhesive application under local anesthesia to standard care.

Bone adhesive is expected to be a functional alternative to miniplate fixation in fracture management.

Team:

Current Members

Dr. Naveen Kumar.J: Co-investigator (HOD) – Penultimate treatment line for fracture repair – A clinical trial using bone adhesive in managing fractured mandible.

Dr. Pearlcid Siroraj.A: Co-investigator (MDS – Lecturer) – Penultimate treatment line for fracture repair – A clinical trial using bone adhesive in managing fractured mandible.

Ms. Pragathi.K: Junior Research Fellow (ICMR) – Penultimate treatment line for fracture repair – A clinical trial using bone adhesive in managing fractured mandible.

Ongoing Projects:

Current (as Primary Investigator)

  1. Effect of Intra-osseous Saline Injections in Pain Management during Surgical Removal of Mandibular Impacted 3rd Molars – A Randomised Double-Blind Study.
  2. Split mouth and parallel arm trial to compare the efficacy of autogenous platelet-rich fibrin, concentrated growth factors and allografts in alveolar bone regeneration around immediately placed titanium dental implants.
  3. Comparing the Effect of Platelet Rich Fibrin and Concentrated Growth Factor for Bone Regeneration on Post Extraction Patients – A Clinical Split Mouth and Parallel Arm Trial.
  4. Penultimate treatment line for fracture repair – A clinical trial using bone adhesive in managing fractured mandible.

Current (as Guide)

  1. Prevalence of alveolar process fracture in patients undergoing intra-alveolar extraction of maxillary 3rd molars – An observational study.
  2. Extraocular Recti Muscles afflictions in patients with Unilateral Zygomatic Maxillary Complex Fracture – A Retrospective, Cross-sectional, Computed Tomographic Study.
  3. Evaluation of extraocular recti muscle changes in patients with unilateral orbital fractures – A prospective, observational, computed tomographic study.
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