Cancer Biology Laboratory
We focus on understanding the mechanisms of DNA repair that can suppress tumor formation.
We employ biochemistry, cell and molecular biology, and next-generation sequencing technologies
to investigate the genome and epigenome of various cell lines, patient tumor samples, and mouse models
to address the following research questions:
- How do cancer cells evade the tumor suppression system by corrupting their DNA repair processes?
- How can we take advantage of the faulty DNA repair processes of cancer cells to kill them?
- How does a cell with damaged DNA communicate with undamaged cells during the cancer development process?
