M. Pharm Pharmacology

Explain mechanism of drug action at organ system/sub cellular/ macromolecular levels.

Demonstrate cellular and organismal function of drug into key stages in preclinical and clinical research studies.

Establish pharmacokinetic/pharmacodynamic (PK/PD), efficacy and toxicology related studiesfor any new drug candidate and to apply these towards the advancement of clinical development.

Discuss strategic approaches for progression from early drug discovery screening to preclinical development, including use of biomarkers.

Describe the pros and cons of different models and select relevant animal models for drug screening.

Optimize animal models for reliability and predictability and translate the preclinical results to clinical studies.

Describe the regulations, ethical requirement and good laboratory practices in conducting efficacy and toxicity studies, maintenance and handling of experimental Animals.

Apply knowledge of pharmacological principle to design and conduct experiments, as well as to analyze and interpret data.

Explain cell-based and molecular assays to characterize therapeutic responses.

Describe the genomic regulation of drug action and application of recombinant DNA technology.

Explain the Proteomics-based biomarker discovery for clinical diagnosis, disease staging/stratification, and understanding drug effects and other biological mechanisms.

Demonstrate the role of genomics, proteomics and bioinformatics in drug discovery.

Demonstrate the properties of drugs and their actions, including the interactions between drug molecules and drug receptors and how these interactions elicit an effect.

Describe and demonstrate the regulatory, ethical requirements for conducting, monitoring and reporting clinical trial

Explain the principles, roles and responsibilities of Pharmacovigilance