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Dr. C. D. Mohana Priya

NephroGenetics Lab 

Research focus of our lab is to intricate interactions between CYP genes, inflammatory markers, and the actin cytoskeletal structure in podocytes, specifically regarding their role in pediatric nephrotic syndrome. We are developing a microRNA panel to evaluate the prognosis of this condition. By leveraging advanced molecular insights, we strive to enhance our understanding of pediatric nephrotic syndrome and create valuable tools for more precise and personalized management strategies.

 

Team 

Current members

 

  • Ms.Pricilla Charmine: ICMR-Senior Research Fellow; Role of miRNAs and their target genes in Childhood Nephrotic Syndrome
  • Ms.Yogalakshmi.V: Research Scholar; Study on Inflammatory markers in Pediatric Nephrotic Syndrome
  • Mr.Praveen Kumar.K.S : Research Scholar:CYP Gene role in Juvenile  Nephrotic Syndrome
  • Mr.Raghul Priyadharson S:Research Scholar;Role of Cytokine genes in Childhood Nephrotic Syndrome

Current Projects

Extramural

  1. Co-Principle Investigator : “Assessment of biochemical mediators during the active and retentive phases of orthodontic treatment and their relation to orthodontic relapse” for the period of one year 2022 awarded by Indian Orthodontic society.grant sanctioned- Ongoing
  2. Member: Workshop on “Advanced molecular biology techniques in dental genetic research” awarded by DHR-ICMR 2021-2024- Ongoing

Intramural

  1. Co-Principle Investigator : Histone Deacetylase 3 (HDAC3) Expression Profile in EGFR Mutant Lung Cancer – Possible Role in Drug Resistance funded by the SRIHER-Young Faculty grant- 2021
  2. Co-Principle Investigator : Role of NGAL in Childhood Kidney Disease funded by the SRIHER-Young Faculty grant- 2021

Past

  1. Principle Investigator : “Urinary microRNAs as potential biomarkers for Childhood Nephrotic Syndrome” as Women Scientists under Biocare scheme, (DBT) for the period of three years 2019-2022 
  2. Principal Investigator: Urinary MicroRNA Profiling in Childhood Nephrotic Syndrome funded by the SRIHER-Young Faculty grant- 2020

Publications

  1. Mohanapriya  C.D, Vettriselvi V, Sangeetha G, Pricilla charmine, Yogalakshmi, Praveen  K. Analysis of microRNAs signatures in juvenile glomerular proteinuria. (2023). Journal of Population Therapeutics and Clinical Pharmacology, 30(16), 342-353. https://doi.org/10.47750/jptcp.2023.30.16.046
  2. Pricilla Charmine, VettriselviV, Sangeetha G, Nammalwar B R, Mohanapriya C.D. A Review on the Role of Actin Cytoskeleton genes of Podocytes in Childhood Nephrotic Syndrome. (2023). Journal of Population Therapeutics and Clinical Pharmacology, 30(16), 330-341https://doi.org/10.47750/jptcp.2023.30.16.045
  3. Venkatachalapathy Y, Suresh PKK, Balraj TH, Venkatesan V, Geminiganesan S, C D MP. Clinico-demographic and biochemical correlation of inflammatory gene expression in pediatric nephrotic syndrome. Mol Biol Rep. 2024 Jul 26;51(1):854. doi: 10.1007/s11033-024-09784-z. PMID: 39060482.
  4. Charmine P, Venkatesan V, Geminiganesan S, Nammalwar BR, Dandapani MC. MicroRNA Expression and Target Prediction in Children with Nephrotic Syndrome. Indian J Nephrol. doi: 10.25259/ijn_47_23
  5. Dandapani MC, Venkatesan V, Charmine P, Geminiganesan S, Ekambaram S. Differential urinary microRNA expression analysis of miR-1, miR-215, miR-335, let-7a in childhood nephrotic syndrome. Mol Biol Rep. 2022 Jul;49(7):6591-6600. doi: 10.1007/s11033-022-07500-3. Epub 2022 May 13. PMID: 35553329. 
  6. Dhandapani MC, Venkatesan V, Pricilla C. MicroRNAs in childhood nephrotic syndrome. J Cell Physiol. 2021 Oct;236(10):7186-7210. doi: 10.1002/jcp.30374. Epub 2021 Apr 5. PMID: 33819345.
  7. Zioni Sangeetha Shankaran, Charles Emmanuel Jebaraj Walter, Arvind Ramanathan, Mohanapriya Chinambedu Dandapani, Sivakumar Selvaraj, Sai Sushmitha Kontham, Thanka Johnson, microRNA-146a gene polymorphism alters human colorectal cancer susceptibility and influences the expression of its target genes in toll-like receptor (TLR) pathway,Meta Gene,Volume 24,2020,100654,ISSN 2214-5400, https://doi.org/10.1016/j.mgene.2020.100654.
  8. Mohanapriya CD, Vettriselvi V, Nammalwar BR, Gowrishankar K, Ekambaram S, Sengutavan P, Venkatachalam P. Novel variations in NPHS1 gene in children of South Indian population and its association with primary nephrotic syndrome. J Cell Biochem. 2018 Dec;119(12):10143-10150. doi: 10.1002/jcb.27351. Epub 2018 Sep 1. PMID: 30171708.
  9. Dhandapani MC, Venkatesan V, Rengaswamy NB, Gowrishankar K, Ekambaram S, Sengutavan P, Perumal V. Report of novel genetic variation in NPHS2 gene associated with idiopathic nephrotic syndrome in South Indian children. Clin Exp Nephrol. 2017 Feb;21(1):127-133. doi: 10.1007/s10157-016-1237-0. Epub 2016 Jan 28. Erratum in: Clin Exp Nephrol. 2017 Feb;21(1):134-135. doi: 10.1007/s10157-016-1259-7. PMID: 26820844.
  10. Dhandapani MC, Venkatesan V, Rengaswamy NB, Gowrishankar K, Nageswaran P, Perumal V. Association of ACE and MDR1 Gene Polymorphisms with Steroid Resistance in Children with Idiopathic Nephrotic Syndrome. Genet Test Mol Biomarkers. 2015 Aug;19(8):454-6. doi: 10.1089/gtmb.2015.0077. Epub 2015 Jul 8. PMID: 26154535.

 

For full publication list, Click here : https://scholar.google.com/citations?user=oXWynIYAAAAJ&hl=en

 

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