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Dr. Teena Koshy

Genetic Determinants of Human Health and Disease:

Our research explores gene variants causing and/or modulating a number of common multigenic disorders, including Parkinson’s disease (PD), dystonia, cancer (pediatric acute lymphoblastic leukemia (ALL) and inherited cancer), polycystic ovarian syndrome (PCOS) and autism spectrum disorders. The disorders were selected on the basis of their prevalence and very significant impact on quality of life, the availability of large patient populations, significant prior knowledge obtained by team members, and the urgent need for and potential major socioeconomic and medical impact of new diagnostics and therapeutics for any one of these conditions. Discoveries of population specific genetic variants associated with such common cancers as breast cancer have important clinical implications, all of this knowledge paving the way for predictive or diagnostic tests relative to these diseases. So far, results of our project have found association of gene variants with risk for PD, PCOS and ALL. 

Team: 

Current members

  1. Ms. Sharon Benita A. Research Scholar (Full Time). Susceptibility to Acute Lymphoblastic Leukaemia- A study on the influence of Genetic polymorphism.
  2. Ms. Rekha S.  Research Scholar (Part time-External). An Integrated Clinical and Genetic study of Dystonia in Indian patients.
  3. Ms. Anitha S. Research Scholar ((Part time-External). Whole Exome Sequencing study of Parkinson’s disease and related endophenotypes in the Indian population.
  4. Ms. Ravinuthala Soundaryalahari. Research Scholar (Part time-External).Comprehensive molecular genetics and phenotype analysis of hereditary cancers in Indian patients.
  5. Dr. Haritha. P.S (Part time-Internal).Identification of genetic basis of mandibular canine impaction and development of prediction tools and intervention protocols.
  6. Ms. Leena Pavitha. (Part time-Internal). Association Of Genetic Polymorphism With Toxicities Of High Dose Methotrexate In Children With Acute Lymphoblastic Leukaemia
  7. Dr. Swathy Yuvraj, (Part time-Internal). Effect of cryopreservation on sperm telomere length and influence of sperm telomere length on intracytoplasmic sperm injection outcomes
  8. Dr. L. Ayesha Nabeela.Vitamin D Receptor Gene Polymorphisms Associated With Childhood Autism

Past members 

  1. Dr. Jiby Jolly Benjamin. 2018-2023 (Full time MD- Ph.D). Study of inflammatory markers, stress markers and cytokine gene polymorphisms among Indian women with polycystic ovarian syndrome.

Projects:

Present 

  1. A study on the association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis, SRIHER GATE, 2022- 2025
  2. Chromosomal sensitivity in directly irradiated and bystander normal and cancer cells after low and high LET irradiation- Board of Research in Nuclear Sciences (A Government of India Initiative), 2023- 2026
  3. A Tiered Bio dosimetry Approach for the Management of Large Scale Radiological and Nuclear Emergencies- Scheme for Promotion of Academic and Research Collaboration (A Government of India Initiative), 2023- 2026
  4. Chromosomal sensitivity in directly irradiated and bystander normal and cancer cells after low and high LET irradiation with its implications for prospective therapy induced delayed health effects- Board of Research in Nuclear Sciences (A Government of India Initiative), 2023- 2026.

Past

  1. Application of Quantitative Fluorescent PCR with short tandem repeat markers to the study of aneuploidies in spontaneous miscarriage- SRIHER GATE- 2010-2013
  2. The Prognostic Significance of Three Fusion Oncogenes in Childhood Acute Lymphoblastic Leukaemia, SRIHER GATE,2014-2017
  3. Study on the genetic variants of thiopurine and folate metabolic pathway and 6-Mercaptopurine -mediated haematological toxicity in childhood acute lymphoblastic leukaemia, Department of Biotechnology (A Government of India Initiative), 2015-2018
  4. Genetics of type 2 diabetes in India: A multicentric population specific family genetics study, Indian Council of Medical Research (A Government of India Initiative) and National Institutes of Health (U.S. Department of Health and Human Services), 2016-2019
  5. A Study on the Association of Endothelial Nitric Oxide Synthase Gene Polymorphisms and the Risk of Chronic Kidney Disease in Indian Patients with Type 2 Diabetes- SRIHER GATE, 2018- 2021
  6. Establishment and capacity building for rapid radiation triage and dose estimation using gene expression biomarker, Atomic Energy Regulatory Board (A Government of India Initiative), 2021-2024

University –Industry Linked Consultancy (UILC)

  1. Jessie Angline B, Consanguinity and hearing impairment in Tamil Nadu: Scope of Genetic Testing and Counseling, Biomedical Science, VIT- 2016
  2. Martina Joshi, DNA variants in the dihydrofolate reductase (DHFR) gene and outcome in childhood acute lymphoblastic lekemia, Biomedical Science, VIT- 2017
  3. Dr. Ravikumar Arunachalam- Mutation Analysis Using Multiplex Ligation-Dependent Probe Amplification in Consanguineous Families in South India with a Child with Profound Hearing Impairment, ENT, SRMC- 2017
  4. P. Shree Preethi & N. Abhinaya- A Study on the association of IL-6 gene polymorphism with male infertility, B.tech GE, Sree Sastha Institute Of Engineering And Technology, 2018
  5. Pricilla Charmine, A study on the role endothelial nitric oxide synthase VNTR (intron 4 a/b) polymorphism on the risk of chronic kidney disease in Indian Patients with Type 2 Diabetes, Biomedical Science, VIT- 2019
  6. Saranya H, A study on the association of the polymorphism G894T of endothelial nitric oxide synthase (eNos) and the risk of chronic kidney disease in Indian Patients with Type 2 Diabetes, Biomedical Science, VIT- 2019
  7. Divya B, A study on the association of DNA repair genes (XPG Asp110His, XRCC5 -VNTR) and the risk of Parkinsons disease, M.Sc. Biotech, DR. D.Y. PATIL VIDHYAPEETH, Pune- 2022
  8. Samriddhi Singh , A study on the association of DNA repair genes (XRCC7 G6721T, XRCC4 intron 3 I/D) and the risk of Parkinsons disease, M. Sc Biological Science, NMIMS Sunandan Divatia School of Science-2022
  9. Vasavi and Suganthi, A study on the assocation of DNA repair genes XRCC5 VNTR and XRCC4 intron 3 I/D with the risk of male infertility, B.tech BT, Vivekandana College of Engineering for Women-2023
  10. Pranesh R, A study of the association of GSTM1 and GSTT1 variants with coronary artery disease, Woodbridge Academy Magnet, USA- 2023
  11.  Suriya Rajasekhran- A study on the role endothelial nitric oxide synthase VNTR (intron 4 a/b) and G894T polymorphism on the risk of coronary artery disease, MBBS, SRIHER- 2023

 

For full list of publications:

https://scholar.google.com/citations?user=vWKqk4QAAAAJ&hl=en&oi=ao

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